Regulatory and Compliance Demands: Knowing the regulatory and compliance structure you should adhere to will affect the data governance you need and how auditable those controls must be.
Define Your Success Criteria: Create the success metrics you would like to see throughout the life cycle before you embark on setting up the program. What do they expect to get out of the program 12, 18, and 24 months down the road? How will they know if the program is successful?
Toolsets and Skills: What tools do you have already? What do you need to procure? Are you going to perform any sort of application rationalization and/or standardization of tools? Or will your individual CDSs decide what works best for them?